Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma.

ABSTRACT:

Background

Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its limited spatial resolution, chromosomal CGH has offered only general information regarding the possible genetic targets of DNA copy number changes.

Methods

In order to further define specific DNA copy number changes in cervical cancer, we analyzed 20 cervical samples (3 pre-malignant lesions, 10 invasive tumors, and 7 cell lines), using the GenoSensor microarray CGH system to define particular genetic targets that suffer copy number changes.

Results

The most common DNA gains detected by array CGH in the invasive samples were located at the RBP1-RBP2 (3q21

SUBMITTER: Hidalgo A 

PROVIDER: S-EPMC1186020 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature