The shared genetic architecture and evolution of human language and musical rhythm.

ABSTRACT: This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic correlations between rhythm, dyslexia and various language-related traits, we adapted multivariate methods to capture genetic signals common to genome-wide association studies of rhythm (N = 606,825) and dyslexia (N = 1,138,870). The results revealed 16 pleiotropic loci (P < 5 × 10^-8) jointly associated with rhythm impairment and dyslexia, and intricate shared genetic and neurobiological architectures. The joint genetic signal was enriched for foetal and adult brain cell-specific regulatory regions, highlighting complex cellular composition in their sha

SUBMITTER: Alagoz G 

PROVIDER: S-EPMC11860242 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature