Associations of MAFLD subtypes and air pollutants with multi-system morbidity and all-cause mortality: A prospective cohort study.

ABSTRACT:

Background

Metabolic dysfunction-associated fatty liver disease (MAFLD) and air pollution are both significant health concerns. However, their combined effects on multi-system morbidity and all-cause mortality remain poorly understood.

Methods

We analyzed data from 434,417 UK Biobank participants, categorizing them into four groups: non-MAFLD, MAFLD-diabetes, MAFLD-lean, and MAFLD-overweight/obesity. To evaluate the long-term effects of air pollution exposure, we used time-varying Cox proportional hazard models to assess four air pollutants: particulate matter with an aerodynamic diameter < 2.5 μm (PM_2.5), PM₁₀, nitrogen dioxide (NO₂), and nitrogen oxides (NO_x). We examined the associations between these air pollutants, MAFLD subty

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11860302 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature