Evaluation of Zein Nanoparticles as Delivery Agents of SARS-CoV-2 Antigens.

ABSTRACT:

Background/objectives

Nanovaccines have significant potential to enhance immunization strategies by improving efficacy, safety, and cost-effectiveness. In particular, organic nanoparticles hold promise for the generation of low-cost nanovaccines obtained by environmentally friendly methods. In this study, the feasibility of using zein nanoparticles (NPs) as carriers for an antigenic peptide (p30) and the receptor binding domain (RBD) from SARS-CoV-2 spike protein was explored.

Methods

A synthesis method for zein NPs was established by combining previously reported techniques, and the resulting NPs were characterized in terms of morphology, particle size, polydispersity index (PDI), surface charge, and colloidal stability using dynamic light scattering (DLS) and transmission

SUBMITTER: Marquez-Escobar VA 

PROVIDER: S-EPMC11860552 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature