Heart failure after left atrial appendage occlusion: Insights from the LAAOS III randomized trial.

ABSTRACT:

Aims

The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III).

Methods and results

Patients (n = 4811) with atrial fibrillation (AF) and a CHA₂DS₂-VASc score ≥2, who were having cardiac surgery for another indication, were randomized to undergo surgical LAAO or not. We compared the composite outcome of HF-related hospitalizations and HF death between the two groups. HF assessment required clinical and radiographic evidence of HF. Analyses included a landmark analysis before and after 30 days and subgroups. Mean age was 71.2 years, 67.5%

SUBMITTER: Krisai P 

PROVIDER: S-EPMC11860722 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature