Observational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION).

ABSTRACT:

Aims

We sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard of care with loop diuretics.

Methods and results

Between September 2022 and March 2023, 44 eligible patients (mean age 66.3 years, 84% male) with ejection fraction <50% and with WHF symptoms in the preceding week treated in an outpatient setting were enrolled. Patients were assessed weekly over 4 weeks following the WHF episode. At week 4, responses to fluid expansion and furosemide administration were assessed in 39 patients to unmask persistent subclinical congestion. Patients were on stable doses of guideline-directed medical therapy (GDMT) with a mean daily furosemide do

SUBMITTER: Cotter G 

PROVIDER: S-EPMC11860726 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature