Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making.

ABSTRACT: Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related parameters, it is unclear whether and how this information is coordinated. To address this question, we performed large-scale single-unit recordings simultaneously across 5 medial/orbital frontal and basal ganglia regions as rats decided whether to pursue varying reward payoffs available at different effort costs. Single neurons encoding combinations of decision variables (reward, effort, and choice) were represented within all recorded regions. Coactive cell assemblies, ensembles of neurons that repeatedly coactivated within short time windows (<25 ms),

SUBMITTER: Harmson O 

PROVIDER: S-EPMC11860760 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature