The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model.

ABSTRACT: Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory diseases, particularly in young children, the elderly and immunocompromised. There are no approved antiviral drugs against this virus. We report that the combination of ribavirin with either remdesivir or its parent nucleoside GS-441524 results in a pronounced antiviral effect against HPIV-3 in LLC-MK2 cells and in human airway epithelial cells grown at the air-liquid interface. In AG129 mice intranasally inoculated with HPIV-3, the combined treatment with ribavirin and GS-441524 decreased infectious viral lung titers by >2.5 log₁₀ to undetectable levels in 4 out of 11 mice and by 1.6 log₁₀ in the remaining 7 mice as compared with the vehicle. The lungs of all mice that received the combined treatm

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11860817 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature