Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization.

ABSTRACT:

Background

Spontaneous coronary artery dissection (SCAD) significantly contributes to myocardial infarction among young individuals. Despite the elusive nature of its etiology, empirical evidence indicates a substantial correlation between sociopsychological factors and the disorder. This investigation endeavored to discern a genetic basis for personality traits influencing SCAD susceptibility.

Methods

Bidirectional univariate and multivariate Mendelian randomization (MR) analyses were hereby conducted to investigate the putative causal nexus between personality dimensions and SCAD risk. Besides, data regarding SCAD and personality were extracted from expansive genome-wide association studies (GWAS), and rigorous statistical inferences were made using inverse variance weight

SUBMITTER: Zheng K 

PROVIDER: S-EPMC11860944 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature