Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation.

ABSTRACT:

Purpose

Tumor-targeted positron emission tomography (PET) and fluorescence-guided surgery (FGS) could address current challenges in pre- and intraoperative imaging of gastric cancer. Adequate selection of molecular imaging targets remains crucial for successful tumor visualization. This study evaluated the potential of integrin α_vβ₆, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), epidermal growth factor receptor (EGFR), epithelial cell adhesion molecule (EpCAM) and human epidermal growth factor receptor-2 (HER2) for molecular imaging of primary gastric cancer, as well as lymph node and distant metastases.

Methods

Expression of α_vβ₆, CEACAM5, EGFR, EpCAM and HER2 was determined using immunohistochemistry in hum

SUBMITTER: Houvast RD 

PROVIDER: S-EPMC11860997 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature