Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

ABSTRACT: Chikungunya fever (CHIKF) is a re-emerging infectious disease caused by the chikungunya virus (CHIKV), transmitted primarily by Aedes mosquitoes. A significant number progress to chronic chikungunya arthritis, which shares similarities with rheumatoid arthritis (RA). Despite evidence of a link between CHIKV infection and subsequent RA development, a comprehensive analysis of the relationship between these two diseases is lacking. This study systematically analyzes the incidence of RA after CHIKV infection and its immunological mechanisms, following PRISMA guidelines with literature searches across multiple databases up to 3 September 2024. Eligible studies included retrospective and prospective designs reporting RA diagnoses after CHIKV infection. Data extraction was performed independentl

SUBMITTER: Amaral JK 

PROVIDER: S-EPMC11861052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature