Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [¹³C]bicarbonate metabolism in mice.

ABSTRACT: Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer's disease. Hyperpolarized [1-¹³C]pyruvate MRS has shown promise for neurological applications because it enables the real-time in vivo detection of glycolysis and oxidative phosphorylation flux. In studies of the mouse brain using hyperpolarized [1-¹³C]pyruvate, there are few reports that the signal of [¹³C]bicarbonate, a product of oxidative phosphorylation metabolized from [1-¹

SUBMITTER: Ono M 

PROVIDER: S-EPMC11861090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature