The gastric microbiome altered by A4GNT deficiency in mice.

ABSTRACT:

Background

Selective antimicrobial effects have been found for α1,4-linked N-acetylglucosamine residues at the terminus of O-glycans attached to a core protein of gastric gland mucin. A4gnt encodes α1,4-N-acetylglucosaminyl transferase, which is responsible for the biosynthesis of α1,4-linked N-acetylglucosamine. The impact of A4GNT on the establishment and homeostasis of the gastric microbiome remains to be clarified. The aim of this study was to characterize the gastric microbiome in mice deficient for the production of α1,4-linked N-acetylglucosamine.

Methods

The gastric microbiome within A4gnt ^-/- mice and wild-type mice was analyzed using high-throughput sequencing of bacterial 16S rRNA.

Results

In A4gnt ^-/- mice, which

SUBMITTER: Gong D 

PROVIDER: S-EPMC11861098 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature