Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review.

ABSTRACT:

Purpose of review

This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Receptor T-cell (CAR-T) cardiotoxicity.

Recent findings

CAR-T therapy has emerged as a groundbreaking treatment for hematological malignancies since FDA approval in 2017. CAR-T therapy is however associated with a few side effects, among which cardiotoxicity is of significant concern. There were only a few studies on CAR-T cardiotoxicity published to date with limited sample sizes, and their findings were heterogeneous. It was difficult to reach generalizable conclusions. CAR-T therapy was associated with significant risks for acute and subacute cardiotoxicity, as measured by echocardiograms, EKG, and blood biomarkers. Patients with cytokin

SUBMITTER: Joseph T 

PROVIDER: S-EPMC11861112 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature