Prognostic value of folate-associated gene expression in stage II colon cancer.

ABSTRACT:

Purpose

Prognostic variability in stage II colon cancer underscores the need for better risk stratification. Analyzing folate-associated gene expression in stage II colon cancer could provide researchers and clinicians with deeper insights into tumor biology and potentially aid in identifying early prognostic and/or predictive biomarkers.

Methods

Patients with stage II colon cancer and recurrence (n = 48) were matched to patients with a 5 year recurrence-free follow-up (n = 133). Gene expression of ABCC3, AMT, FPGS, GGH, MFT, PCFT, RFC-1, and TYMS was analyzed in tumor tissue and matching colon mucosa using qPCR and evaluated in relation to time to recurrence (TTR), as well as to demographic and clinicopathological variables.

Results

Independent of other covariates, T

SUBMITTER: Kaidi D 

PROVIDER: S-EPMC11861115 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature