Oxytocin differentially modulates reward system responses to social and non-social incentives.

ABSTRACT:

Rationale

Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and reproductive behavior, yet little is known about how oxytocin differentially influences neural responses to social and non-social incentives.

Objectives

We aimed to evaluate the effects of oxytocin administration on behavioral and neural responses to social and monetary incentives.

Methods

Twenty-eight healthy adults (age 18-45 years) performed both monetary and social incentive tasks during blood oxygenation level dependent (BOLD) imaging. Intranasal oxytocin or placebo was administered before each scan using a double blind, randomized, cross-over design. Task performance and self-reported motivation and mood states were collected. Time-serie

SUBMITTER: Thurston MD 

PROVIDER: S-EPMC11861123 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature