Efficacy of LaAg Vaccine Associated with Saponin Against Leishmania amazonensis Infection.

ABSTRACT:

Background/objectives

The total lysate of Leishmania amazonensis (LaAg) is one of the most extensively studied vaccine formulations against leishmaniasis. Despite demonstrating safety and immunogenicity when administered intramuscularly, LaAg has failed to show efficacy in clinical trials and, in some cases, has even been associated with an enhanced susceptibility to infection. Adjuvants, which are molecules or compounds added to antigens to enhance the immunogenicity or modulate the immune response, are frequently employed in vaccine studies. This study aimed to evaluate different adjuvants to improve the protective efficacy of LaAg in L.amazonensis infection using a BALB/c mouse model.

Methods

BALB/c mice were immunized with LaAg in combination with various a

SUBMITTER: de Mello MF 

PROVIDER: S-EPMC11861163 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature