Metabolomic and genomic insights into Micromonospora carbonacea subsp. caeruleus for anti-colorectal compound.

ABSTRACT: Cancer is a predominant contributor to global morbidity and mortality, affecting populations worldwide. Marine Micromonospora species have been identified as significant sources of anticancer compounds. This work aimed to perform a polyphasic approach of isolated strain and conduct comparative metabolomic and genomic analyses to identify compounds with anticancer activity. The study utilized a polyphasic approach on isolated strains for anticancer compound identification. Taxonomic analysis of strain 2MTK254 revealed unique pigment and fatty acid patterns, designating it as a novel Micromonospora carbonacea subsp. caeruleus. Its crude extract displayed significant anti-colorectal activity (66.03% inhibition). Molecular network analysis classified metabolites into eight classes, highlightin

SUBMITTER: Kongsaya T 

PROVIDER: S-EPMC11861244 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature