Short-term overloading exercise attenuates articular chondrocyte features partly via synovium-cartilage interactions mediated by inhibin subunit beta A.

ABSTRACT: Excessive mechanical loading leads to cartilage degeneration. However, short-term responses of the synovium and cartilage to overloading and interactions between these tissues remain poorly understood. We developed a mouse model to study excessive mechanical loading, combining treadmill exercise with weight attachment. Time-course RNA sequencing of the synovium and cartilage displayed transient upregulation of inflammation after single overloading, whereas it was prolonged by repeated overloading. Ingenuity pathway analysis identified Inhba, encoding inhibin subunit beta A, as an upstream molecule for the cartilage transcriptomic changes. Inhba was highly induced by single or repeated overloading in the synovium, and Inhba protein was detected in the superficial layer of the synovium. Supp

SUBMITTER: Arino Y 

PROVIDER: S-EPMC11861322 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature