Fluoride-Mediated Immune Damage Through Cytokine Network Regulation of Tregs.

ABSTRACT: Long-term fluoride exposure can induce inflammatory responses in various tissues of the body, thereby affecting the inflammatory microenvironment. To explore how fluoride induces changes in immune function within this microenvironment, this study collected baseline information and biological samples from participants in areas with the drinking water type of fluorosis, and simultaneously established Wistar rat models with a 12-week and 24-week fluoride exposure, as well as a 12-week fluoride exposure followed by 12-week pure water feeding regimen. Luminex multiplex assays and enzyme-linked immunosorbent assays (ELISAs) were used to measure cytokine expression levels. Subsequently, correlation analysis, multiple linear regression, and mediation analysis were employed to explore the long-term

SUBMITTER: Liu B 

PROVIDER: S-EPMC11861542 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature