CD21^low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation.

ABSTRACT:

Background

The posttranslational modification of cellular macromolecules by glycosylation is considered to contribute to disease pathogenesis in autoimmune and inflammatory conditions. In a subgroup of patients with common variable immunodeficiency (CVID), the occurrence of such complications is associated with an expansion of naïve-like CD21^low B cells during a chronic type 1 immune activation. The glycosylation pattern of B cells in CVID patients has not been addressed to date.

Objective

The objective of this study was to examine the surface glycome of B cells in patients with CVID and associated immune dysregulation.

Methods

We performed surface lectin staining on B cells from peripheral blood and tonsils, both ex vivo and after in vitro st

SUBMITTER: Felixberger PT 

PROVIDER: S-EPMC11861550 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature