The Role of Epigenetic Mechanisms in the Development of PM_2.5-Induced Cognitive Impairment.

ABSTRACT: PM_2.5 is fine particulate matter with a diameter of less than 2.5 μm. Recent evidence has shown that exposure to PM_2.5 markedly elevates the risk of neurodegenerative diseases, neurodevelopmental disorders, and cardiovascular diseases, which may culminate in cognitive impairment. Nevertheless, the precise mechanisms through which PM_2.5 affects cognitive function are unclear. Recent studies have demonstrated that PM_2.5-induced epigenetic alterations are associated with the development of cognitive impairment. Epigenetic alterations include modifications to DNA methylation, histone modifications, and non-coding RNAs. The underlying mechanisms of epigenetic alterations are related to inflammation, synaptic dysfunction, cardiovascular factors, and al

SUBMITTER: Jiang L 

PROVIDER: S-EPMC11861554 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature