Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review.

ABSTRACT:

Background

Primary clear cell adenocarcinoma of the urethra (CCAU) is a kind of extremely rare genitourinary cancer. Despite the similarity in the clinical manifestations of these reported cases, diagnosis and determination of standard therapy remain challenging due to the rarity of findings and similarity with other urethral tumors.

Case presentation

Herein, we reported two cases of CCAU with the same chief complaint of hematuria: a 71-year-old female and a 66-year-old male. The male patient reported concomitant symptoms of frequent and painful urination. CT scans show abnormal enhancements. After a cystoscopy examination, both patients are diagnosed with malignant urethral tumors. Surgical resections and additional pathological examinations support the diagnosis of CCAU (p

SUBMITTER: Jiang B 

PROVIDER: S-EPMC11861585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature