Biomarkers of Fumonisin Exposure in Pigs Fed the Maximum Recommended Level in Europe.

ABSTRACT: This study investigated biomarkers of fumonisin exposure in pigs fed diets contaminated with fumonisins at the European Union's maximum recommended level. Pigs were assigned to either a fumonisin (FB) diet or a fumonisin plus AlgoClay (FB + AC) diet for durations of 4, 9, and 14 days. At 14 days, the plasma Sa1P:So1P ratio increased in pigs fed the FB diet, while the Sa:So ratio remained unchanged. In the liver, FB1 was detected at four days of exposure, with the concentration tending to increase through day 14. The Sa:So and C22-24:C16 ratios of 18:1-, 18:2-, and m18:1-ceramides were elevated at 9 and 14 days, respectively. In the kidneys, FB1 was only detectable at 14 days, and the Sa:So and C22-24:C16 ratios of 18:1-ceramides were increased. In both the liver and kidneys, the increase i

SUBMITTER: Lassallette E 

PROVIDER: S-EPMC11861712 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature