CDX2 and SATB2 loss are associated with myeloid cell infiltration and poor survival in colorectal cancer.

ABSTRACT:

Background

Caudal-type homeobox 2 (CDX2) and special AT-rich sequence-binding protein 2 (SATB2) are transcription factors playing important roles in intestinal homeostasis and participating in the regulation of intestinal inflammation. In colorectal cancer (CRC), reduced expression levels of CDX2 and SATB2 have been associated with poor differentiation and worse survival. However, their prognostic significance still needs further clarification, and the associations between CDX2 and SATB2 and immune cell infiltration into the CRC microenvironment are largely unknown.

Methods

We analyzed CDX2 and SATB2 expression in two large cohorts of stages I-IV CRC patients (N = 2302) and analyzed their associations with clinicopathologic parameters, the density of local immune cells (dete

SUBMITTER: Sirnio P 

PROVIDER: S-EPMC11861821 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature