Study on pathological factors affecting the sensitivity of neoadjuvant therapy in hypopharyngeal cancer.

ABSTRACT:

Objective

Hypopharyngeal squamous cell carcinoma (HSCC) is a highly malignant tumor type in the head and neck region. In recent years, neoadjuvant therapy has significantly improved the laryngeal preservation rate among patients. However, there are variations in the efficacy of neoadjuvant therapy, and the identification of reliable predictive biomarkers for its efficacy remains a challenging research focus. This study aims to explore the correlation between the expression of P53, P16, and Ki67 and the response to neoadjuvant therapy.

Methods

A retrospective analysis was conducted on 120 patients who underwent neoadjuvant therapy at Beijing Tongren Hospital, Capital Medical University, from January 2021 to June 2024. Patients were grouped based on their treatment response an

SUBMITTER: Yin G 

PROVIDER: S-EPMC11861825 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature