Outer Membrane Proteins as Vaccine Targets Against Lawsonia intracellularis in Piglets.

ABSTRACT:

Background

Lawsonia intracellularis (LI) is the agent of proliferative enteropathy in swine, a common disease that affects pigs for up to eight weeks after weaning.

Aim

To evaluate the effectiveness of two novel subunit vaccines targeting outer membrane proteins on LI.

Methods

The two vaccines included OMP2c.cVLP, where the OMP2c antigen was anchored on the surface of capsid virus-like particles (cVLP); and MBP.INVASc, where antigens were anchored to an MBP fusion protein. Groups of six mice, as proof of concept, and six piglets were immunized with either OMP2c.cVLP, MBP.INVASc., or PBS as a control using a prime-boost regime.

Results

Both OMP2c.cVLP and MBP.INVASc subunit vaccines induced strong antigen-specific serum IgG and IgA responses. There were n

SUBMITTER: Aves KL 

PROVIDER: S-EPMC11861839 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature