What Do Mismatch Negativity (MMN) Responses Tell Us About Tinnitus?

ABSTRACT: Due to the heterogeneous causes, symptoms and associated comorbidities with tinnitus, there remains an unmet need for a clear biomarker of tinnitus presence. Previous research has suggested a "final pathway" of tinnitus presence, which occurs regardless of the specific mechanisms that resulted in alterations of auditory predictions and, eventually, tinnitus perception. Predictive inference mechanisms have been proposed as the possible basis for this final unifying pathway. A commonly used measure of prediction violation is mismatch negativity (MMN), an electrical potential generated in response to most stimuli that violate an established regularity. This narrative review discusses 16 studies comparing MMN between tinnitus and non-tinnitus groups. Methods varied considerably, including type

SUBMITTER: Yukhnovich EA 

PROVIDER: S-EPMC11861849 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature