Gut Microbiota Regulates Food Intake in a Rodent Model of Intermittent Limited Access to Palatable Food.

ABSTRACT:

Objective

Binge-eating disorder is characterized by recurrent episodes of consumption of large amounts of food within a short period of time, without compensatory purging behaviors. This disease is a major public health issue and is associated with numerous comorbidities, encompassing anxiety and depression. The gut microbiota has been proposed to be an important player in the onset or maintenance of eating disorders. Here, we aim to better delineate the potential role of the gut microbiota in binge-eating disorder.

Method

We used a model of intermittent limited access to palatable food where eight-week-old C57Bl/6 female mice had access during 2 h, every 2 days over a 10-day period, to a high-fat/high-sucrose diet. Half of the animals received antibiotics to deplete their g

SUBMITTER: Demangeat T 

PROVIDER: S-EPMC11861880 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature