Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease.

ABSTRACT: Naïve CD4 T cells are traditionally viewed as a quiescent, homogeneous, resting population, but emerging evidence reveals their heterogeneity, which can be crucial for understanding disease contexts and therapeutic outcomes. In this study, we identify distinct subpopulations within both murine and human naïve CD4 T cells by single cell-RNA-sequencing (scRNA-seq), particularly focusing on a subpopulation that expresses super-high levels of interleukin-7 receptor (IL-7R^sup-hi), along with CD97, IL-18R, and Ly6C. This subpopulation, absent in the thymus and peripherally induced, exhibits type 1 helper T cell (Th1)-poised characteristics and contributes to the inhibition of cancer progression in B16F10 tumor-bearing mice. In humans, this IL-7R^sup-hi subpopulation expressi

SUBMITTER: Yoon JW 

PROVIDER: S-EPMC11861895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature