Identification of a novel unfolded protein response related signature for predicting the prognosis of acute myeloid leukemia.

ABSTRACT: The unfolded protein response (UPR) plays a pivotal role in the pathogenesis and progression of acute myeloid leukemia (AML). This study aims to investigate the prognostic value of UPR-related genes (URGs) and establish a UPR-related gene signature (URGsig) to enhance prognosis prediction and guide therapeutic decision-making in AML. Gene expression profiles of AML patients were obtained from the GDC and GEO databases. Cox regression and LASSO regression analyses were applied to identify key genes for the construction of URGsig. Comprehensive bioinformatics analyses were conducted to elucidate the biological and clinical implications of URGsig. A nomogram integrating URGs and clinical prognostic features was developed to predict survival probability for AML patients. Additionally, the diff

SUBMITTER: Fei L 

PROVIDER: S-EPMC11861913 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature