Multilayer analysis of ethnically diverse blood and urine biomarkers for breast cancer risk and prognosis.

ABSTRACT: Breast cancer (BC) is one of the most common malignancies among women globally, characterized by complex pathogenesis involving various biomarkers present in blood and urine. To enhance understanding of the genetic associations between biomarkers and BC via multidimensional, cross ethnic investigations. Based on GWAS data of 35 blood and urine biomarkers from European populations, we adopted multiple analysis strategies including univariable Mendelian randomization (MR) analysis, reverse MR analysis, sensitivity analysis and multivariate MR to identify potential biomarkers associated with BC risk and survival. Our initial analysis included 122,977 BC and 105,974 controls of European ancestry. Building upon these findings, we conducted cross ethnic validation by applying the same analyses t

SUBMITTER: Feng J 

PROVIDER: S-EPMC11861975 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature