Prognostic Impact of Oncogenic Fibroblast Growth Factor Receptor Alterations in Patients With Advanced Solid Tumors in a Real-World Setting.

ABSTRACT:

Background

Somatic FGFR gene alterations (FGFRalt) may act as oncogenic drivers across several cancers. The prognostic impact of FGFRalt in solid tumors is not fully understood. We assessed the prognostic impact of FGFRalt on overall survival (OS) in a tumor-agnostic real-world cohort of patients with advanced solid tumors.

Methods

This was a retrospective, observational, comparative cohort analysis that used data from a nationwide de-identified clinico-genomic database. Patients were included if they had advanced/metastatic disease, were aged ≥ 18 years at the time of diagnosis, had evidence of genomic testing for FGFRalt, and had initiated first-line systemic therapy for their cancer. Patients without FGFR alterations (FGFRneg) were matched 3:1 with patients with FGFRalt u

SUBMITTER: Demirdjian L 

PROVIDER: S-EPMC11862098 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature