Rates of female mouse ultrasonic vocalizations are low and are not modulated by estrous state during interactions with muted males.

ABSTRACT: Adult male mice produce high rates of ultrasonic vocalizations (USVs) during courtship interactions with females. It was long thought that only males produced courtship USVs, but recent studies using microphone arrays to assign USVs to individual signalers report that females produce a portion (5-18%) of total courtship USVs. The factors that regulate female courtship USV production are poorly understood. Here, we tested the idea that female courtship USV production is regulated by estrous state. To facilitate the detection of female USVs, we paired females with males that were muted for USV production via caspase-mediated ablation of midbrain neurons that are required for USV production. We report that total USVs recorded during interactions between group-housed B6 females and muted males

SUBMITTER: Malone CA 

PROVIDER: S-EPMC11862114 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature