LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity.

ABSTRACT:

Background

WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 regulates fat distribution and its effects on systemic metabolism remain unclear. This study aims to explore the role of LRP5 in adipose tissue biology and its impact on metabolism.

Methods

Metabolic assessments and imaging were conducted on individuals with gain- and loss-of-function LRP5 mutations, along with age- and BMI-matched controls. Mendelian randomization analyses were used to investigate the relationship between bone, fat distribution, and systemic metabolism. Functional studies

SUBMITTER: Loh NY 

PROVIDER: S-EPMC11862225 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature