Comparative study of mouse models of atopic dermatitis.

ABSTRACT: Atopic dermatitis (AD) is a chronic, recurrent inflammatory disease. Animal models are important for studying disease mechanisms and identifying new therapeutic agents. However, owing to AD heterogeneity and complexity, there is currently no mouse model that can fully simulate human AD. We searched experimental articles published between 2017 and 2021 to identify the most suitable AD mouse model. We summarized and compared 614 articles, including details on mouse strains, sex, age, irritants, modeling cycles, and spontaneous mouse models. BALB/c mice (45.3 %) were the most commonly used. Generally, 4-8-week-old mice were used, and 44 irritants were identified. The most common irritant was 2,4-dinitrochlorobenzene (DNCB), followed by Dermatophagoides farinae mite antigen extract (DfE

SUBMITTER: Ye S 

PROVIDER: S-EPMC11862492 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature