Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease.

ABSTRACT:

Objective

To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses.

Method

We utilized large-scale plasma and brain protein quantitative trait loci (pQTL) datasets from the deCODE Health study and the Religious Orders Study/Rush Memory and Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using the OTTERS framework for plasma proteins and the FUSION tool for brain proteins, examining associations with PD onset and three progression phenotypes: composite, motor, and cognitive. Significant protein associations (FDR-corrected p < 0.05) from PWAS were further validated using sum

SUBMITTER: Gao C 

PROVIDER: S-EPMC11862824 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature