In vitro and in silico studies of the interaction between glucocorticoid drug mometasone furoate and model lung surfactant monolayer.

ABSTRACT: In an effort to treat preterm neonates who are already suffering or are at high risk for chronic pulmonary illness, the comprehensive investigation has recently been focused on the intratracheal administration of corticosteroid drugs employing an innate lung surfactant as a drug carrier. A novel approach to utilize exogenous surfactant preparation as a drug delivery vehicle for corticosteroids, which are the inflammation-reducing agents for lung diseases has not been comprehensively investigated. The direct corticosteroid drugs administered through pulmonary surfactants would impair their surface activity and exacerbate normal breathing cycles. This study was conducted to characterize the physiological interaction between frequently used inhaled corticosteroid, mometasone furoate, and rele

SUBMITTER: Islam MZ 

PROVIDER: S-EPMC11862883 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature