Deuterium Metabolic Imaging of the Brain Using 2-Deoxy-2-[²H₂]-d-glucose: A Non-ionizing [¹⁸F]FDG Alternative.

ABSTRACT: The positron emission tomography (PET) tracer 2-deoxy-2-[¹⁸F]fluoroglucose ([¹⁸F]FDG) is widely used to study diseases where glucose metabolism is dysregulated, including cancer and neurodegenerative disorders. Here we investigate the hypothesis that the 2-position deuterium-enriched analogue 2-deoxy-2-[²H₂]-d-glucose (2-DG-d2) can also map glucose uptake using deuterium metabolic imaging (DMI) without ionizing radiation. To accomplish this, we used a spectrally selective multiband radiofrequency pulse and balanced steady-state free procession (bSSFP) technique, enabling rapid ²H imaging with high specificity and sensitivity to 2-DG-d2. Both in vitro and in vivo validations demonstrated the sequence's ability to suppress

SUBMITTER: Gao X 

PROVIDER: S-EPMC11862922 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature