Phenylpyrazoles as Inhibitors of the m⁶A RNA-Binding Protein YTHDF2.

ABSTRACT: The N6-methyladenosine (m⁶A) modification, which is the most common RNA modification in eukaryotes, is regulated by the "writer" methyltransferases, the "reader" m⁶A binding proteins, and the "eraser" demethylases. m⁶A plays a multifunctional role in physiological and pathological processes, regulating all aspects of RNA metabolism and function, including RNA splicing, translation, transportation, and degradation. Accumulating evidence suggests that the YT521-B homology domain family 2 (YTHDF2), one of the m⁶A "readers," is associated with various biological processes in cancers and noncancerous disorders, impacting migration, invasion, metastasis, proliferation, apoptosis, and cell cycle. Here, we describe our work in the identification o

SUBMITTER: Qiu X 

PROVIDER: S-EPMC11862924 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature