Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis.

ABSTRACT: Herein, we report a scalable and mild strategy for the monofluoroalkylation of a wide array of Giese acceptors via visible-light-mediated photoredox catalysis in continuous flow. The use of flow technology significantly enhances productivity and scalability, whereas mildness of conditions and functional group tolerance are ensured by leveraging 4CzIPN, a transition-metal-free organic photocatalyst. Structurally diverse secondary and tertiary monofluoroalkyl radicals can thus be accessed from readily available α-monofluorocarboxylic acids. Given the mild reaction conditions, this protocol is also amenable to the late-stage functionalization of biologically relevant molecules such as menthol, amantadine, bepotastine, and estrone derivatives, rendering it suitable for application to drug disc

SUBMITTER: Pasca F 

PROVIDER: S-EPMC11862961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature