Association of Serum Symmetric Dimethylarginine Concentrations and Inflammation in Cats.

ABSTRACT:

Background

Serum symmetric dimethylarginine (SDMA) concentrations are higher in some hyperthyroid cats with normal renal function, presumably due to increased protein catabolism.

Objectives

To investigate if SDMA is higher in cats with inflammation (defined as elevated serum amyloid A [SAA]).

Animals

Twenty-eight cats: 12 with elevated SAA concentrations (> 3.9 μg/mL) and 16 with normal SAA.

Methods

Retrospective case control study. Cats presenting to a referral institution between 2016 and 2022 with a documented SAA were identified. Individuals with renal and extrarenal factors known to affect SDMA were excluded. SDMA was measured from stored serum samples. Comparisons were made using the Mann-Whitney U test, and correlations assessed using Spearman's correlat

SUBMITTER: Cattaneo G 

PROVIDER: S-EPMC11863204 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature