Incidence and Risk Factors of Zidovudine-Induced Anemia in Patients With HIV Infection Receiving Zidovudine-Containing Antiretroviral Therapy.

ABSTRACT:

Background

Anemia is among the frequently observed conditions among people living with HIV (PLWH). Zidovudine (AZT) is the most common ART that causes anemia. This study aimed to identify the incidence and risk factors of AZT-induced anemia in PLWH receiving AZT-containing regimens.

Methods

A retrospective cohort study was conducted on nonpregnant PLWH aged >18 years who received AZT-containing regimens for >6 months and had normal baseline hemoglobin levels. Data on medical history, clinical characteristics, and laboratory examination were collected. Cox proportional hazard regression analysis was performed to determine the risk factors of AZT-induced anemia.

Results

A total of 401 individuals were included in the study. In total, 71 individuals presented with AZT-in

SUBMITTER: Boonyagars L 

PROVIDER: S-EPMC11863231 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature