Incidence of alternative splicing associated with sex and opioid effects in the axon guidance pathway.

ABSTRACT: The alternative splicing of a gene results in distinct transcript isoforms that can result in proteins that differ in function. Alternative splicing processes are prevalent in the brain, have varying incidence across brain regions, and can present sexual dimorphism. Exposure to opiates and other substances of abuse can also alter the type and incidence of the splicing process and the relative abundance of the isoforms produced. The disruption of alternative splicing patterns associated with sex differences and morphine exposure in the prefrontal cortex of a pig model was studied. The numbers of genes presenting one or more significant (FDR-adjusted p-value < 0.05) alternative splicing events were 933 and 1,368 genes when comparing females relative to males and morphine- relative to saline-

SUBMITTER: Southey BR 

PROVIDER: S-EPMC11863264 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature