Effect of older age and/or ACL injury on the dose-response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein.

ABSTRACT:

Purpose

This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP(t_pre)) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP(t_post)), and on the dose-response relationship between ambulatory load magnitude and ∆_sCOMP(t_post).

Methods

A total of 85 participants were recruited in 4 groups (20-30 years: 24 healthy, 23 ACL-injured; 40-60 years: 23 healthy, 15 ACL-injured). Blood samples were collected immediately before and after a walking stress at 80%, 100%, or 120% bodyweight (BW) on 3 test days and analyzed for sCOMP concentration. Linear models were used to estimate the

SUBMITTER: Herger S 

PROVIDER: S-EPMC11863317 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature