Cold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults.

ABSTRACT:

Background

Measures of energy metabolism (energy expenditure [EE], respiratory exchange ratio [RER]) have been associated with ad libitum energy intake (EI) and weight gain in previous observational studies, suggesting that energy-sensing mechanisms drive EI to meet metabolic energy demands.

Objectives

We aimed to employ mild cold exposure as an intervention to alter energy metabolism and evaluate its causal effects on concurrent and next day ad libitum EI.

Methods

In a controlled crossover study, 47 volunteers (16 female; age 37.2 ± 10.7 y; body mass index 32.4 ± 8.6 kg/m²) completed four 24-h EE measurements in a respiratory chamber. Participants ate ad libitum for 24-h using an objective vending machine paradigm while in the chamber during both cold expo

SUBMITTER: Unlu Y 

PROVIDER: S-EPMC11863325 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature