A Half-Sandwich Os(II) Glucoconjugated NHC Complex as a Modulator of Amyloid Aggregation.

ABSTRACT: Herein, the effects of a novel half-sandwich Os(II) complex on the aggregation of an amyloid model system, derived from the C-terminal domain of the nucleophosmin 1 protein (NPM1_264-277), were investigated. The thioflavin T (ThT) binding assay revealed that the complex [(η⁶-toluene)Os(NHCglu)Cl₂] (where NHCglu is the N-heterocyclic carbene ligand 1-methyl-3-{2,3,4,6-tetra-O-acetyl-1-glucosyl}imidazol-2-ylidene), hence named Os-Tolu, was able to repress amyloid aggregation in a dose-dependent way. Conformational studies through circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopies clearly indicated that this inhibitory effect occurred through the stabilization of α-helical structures of monomeric NPM1_264-277, t

SUBMITTER: Florio D 

PROVIDER: S-EPMC11863378 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature