Bridging therapy with histotripsy prior to liver transplantation for hepatocellular carcinoma: a first case report.

ABSTRACT:

Background

Histotripsy is a novel, non-invasive, non-ionizing, and non-thermal ablation technique that disrupts tumors using acoustic cavitation. We report the first use of Histotripsy as bridging therapy prior to liver transplant for hepatocellular carcinoma (HCC) treated with histotripsy.

Case presentation

A 59-year-old woman presented with Metabolic-Associated Steatotic Liver Disease (MASLD) cirrhosis (labMELD = 14), hepatic encephalopathy, and a single 2 cm OPTN V lesion in the left lateral segment consistent with HCC. The patient underwent histotripsy treatment of the lesion as bridging therapy before receiving liver transplantation. Histopathology analysis of the explanted liver showed total necrosis of the treated area, with no residual viable tissue tumor.

Conclus

SUBMITTER: Uysal M 

PROVIDER: S-EPMC11863397 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature