Mediation of the association between education and dementia by occupational complexity, income, health behaviours and health outcomes.

ABSTRACT:

Background

Many studies observe a negative association between education and all-cause dementia, however, little is known about how the association develops. Current evidence regarding mediatory factors is limited, conflicted and suggests a complex relationship. In this study we used UK Biobank data to determine to what extent multiple factors mediate the association.

Methods

Data was sourced from UK Biobank and multiple imputation used to replace missing values. Education was measured at baseline assessment and dementia diagnosis determined from self-report or linked healthcare records. Five potential mediators were considered: Social isolation, income and occupational complexity were measured at baseline and health behaviour and health outcome scores derived. Logistic regr

SUBMITTER: Taylor K 

PROVIDER: S-EPMC11863402 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature