Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer.

ABSTRACT:

Background

Tumor heterogeneity and clonal evolution are related to the treatment resistance and disease progression in metastatic breast cancer (MBC). However, the process of clonal evolution and their relationship to prognosis remain unclear. This study aimed to elucidate the evolution of MBC through circulating tumor DNA (ctDNA) analysis and to develop a novel indicator for predicting treatment efficacy and prognosis.

Methods

This multicenter retrospective study enrolled MBC patients who underwent next-generation sequencing between April 2016 and October 2022. The clonal evolution of tumors was inferred using PyClone and CITUP software.

Results

The study included 406 MBC patients. A cohort of 139 patients from the National Cancer Center served as the training cohort

SUBMITTER: Lv D 

PROVIDER: S-EPMC11863457 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature